3Z Drug Information
3Z companies and manufacturers:
3Z forms, composition and dosages:
- N / A
Indications, usages and classification codes:
- J01FA10 - Azithromycin
There is an additional general information about this medication active ingredient azithromycin:
Pharmacological actionAzithromycin is an macrolide antibiotic of azalides group. This medication inhibits RNA-dependent protein synthesis of sensitive microorganisms.
It active against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes group A); gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp., Legionella pneumophila; anaerobic bacteria: Bacteroides fragilis.
PharmacokineticsThis drug rapidly absorbed from the gastrointestinal tract. Ingestion reduces the absorption of azithromycin. Cmax in plasma is reached after 2-3 hours. This medicine rapidly distributed in tissues and biological fluids. 35% of the azithromycin is metabolized in the liver by demethylation. More than 59% is excreted in the bile in unchanged form, about 4.5% in the urine in unchanged form.
Why is 3Z prescribed?Infectious-inflammatory diseases caused by microorganisms susceptible to azithromycin, including bronchitis, pneumonia, infections of skin and soft tissue, otitis media, sinusitis, pharyngitis, tonsillitis, gonorrheal and non gonorrheal urethritis and / or cervicitis, Lyme disease (borreliosis).
Dosage and administrationDosage is setted individually according to nosology, disease severity and sensitivity of the pathogen. Dosage for adults for oral administration is 0.25-1 g 1 time/day; for children - 5-10 mg/kg 1 time/day. The duration of administration is 2-5 days.
3Z side effectsDigestive system: nausea, vomiting, flatulence, diarrhea, abdominal pain, transient elevation of liver enzymes, rarely - cholestatic jaundice.
Allergic reactions: rarely - a skin rash, angioedema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Dermatological reactions: rarely - photosensitization.
CNS: dizziness, headache, rarely - drowsiness, weakness.
Hematopoietic system: rarely - leukopenia, neutropenia, thrombocytopenia.
Cardiovascular system: rarely - chest pain.
Urogenital system: vaginitis, rarely - candidiasis, nephritis, increased residual nitrogen urea.
Other: rarely - hyperglycemia, arthralgia.
ContraindicationsHypersensitivity to azithromycin and other macrolide antibiotics.
Using during pregnancy and breastfeedingAzithromycin crosses the placental barrier. Use in pregnancy only in cases where the intended benefits to the mother outweighs the potential risk to the fetus.
If necessary to use azithromycin in the lactation period should solve the issue of termination of breastfeeding.
Special instructionsThis drug not recommended for use in patients with compromised liver function.
Azithromycin uses with careful with impaired renal function.
This medication should be taken at least 1 hour before or 2 hours after eating or taking of antacids.
3Z drug interactionsSimultaneous administration of azithromycin with these drugs and medications may has followed effects:
PLEASE, BE CAREFUL!
Be sure to consult your doctor before taking any medication!
- Achromycin (Wyeth; Bausch and Lomb; Lederle; Riemser Arzneimittel; Sigma Pharmaceuticals; Storz)
- Achromycin V (Wyeth; Clonmel Healthcare; Lederle; Sigma Pharmaceuticals)
- Achromycine (Lederle)
- Aciderm (Sanval Comercio e Industria)
- Acne Hermal (Olvos Science)
- Acneclin (Valeant Pharmaceuticals)
- Acnecolor (Spirig Pharma)
- Acne-Cy-Clean (Brovar S & P)
- Acnepas E (Atlas Farmaceutica)
- Acneryne (Galderma)
- Acnesol (Systopic Laboratories)
- Acnetrim (Trima Pharmaceuticals; Green Cross)
- Acromicina (Wyeth)
- Actidox (Saninter)
- Actin (Siam Medicare)
- Actisite (ALZA; Dentaid; GABA; Meda; Solco Basel; Willvonseder & Marchesani)
- Acuco (Apotex)
- Acu-Erylate S (Apotex)
- Aculfin (Apsen Farmaceutica)
- Adco-Dermed (Adcock Ingram)
- Amizin (Giempi Laboratorios)
- Amovin (Cofasa Laboratorios)
- Amsati (Antibioticos de Mexico)
- Aruzilina (Leti Laboratorios)
- Arzomicin (Altana Pharma)
- Arzomicina (Farma-APS)
- Arzomidol (Especialidades Dollder)
- Asipral (Labomed Instituto Farmaceutico)
- Atizor (Medipharm, Chile)
- Atromicin (Teuto-Brasileiro Laboratorio)
- Atromizin (Compania Anonima Farmaceutica)
- Azasite (Insite Vision; Inspire)
- Azatill (Prodotti Laboratorio Farmaceutico)
- Azee (Cipla)
- Azi (Novaquimica Sigma Pharma-Nature's Plus)
- Azibact (Ipca Laboratories)
- Azidromic (Royton Quimica Farmaceutica)
- Azifast (Ipca Laboratories)
- Azigram (Vivax Pharmaceuticals)
- Azimakrol (Roemmers-Klinos)