Neupogen manufacturers, companies, ingredients, composition, doses, indications, usages and lots more!

Neupogen Drug Information

Neupogen category:

Active ingredients:

Neupogen companies and manufacturers:

Neupogen forms, composition and dosages:

  • Injectable; Injection; Filgrastim (R-Methug-CSF) 30 MU
  • Injectable; Injection; Filgrastim (R-Methug-CSF) 48 MU

Indications, usages and classification codes:

  • L03AA02 - Filgrastim

Information for Patients and Caregivers

This patient package insert provides information and instructions for people who will be
receiving NEUPOGEN® and their caregivers.  This patient package insert does not tell
you everything about NEUPOGEN®.  You should discuss any questions you have about
treatment with NEUPOGEN®  with your doctor.  

What is NEUPOGEN®?

NEUPOGEN® is a man-made form of granulocyte colony-stimulating factor (G-CSF),
which is made using the bacteria E coli.  G-CSF is a substance naturally produced by
the body.  It stimulates the growth of neutrophils (nu-tro-fils), a type of white blood cell
important in the body’s fight against infection.

What is NEUPOGEN® used for?

NEUPOGEN® is used to treat neutropenia (nu-tro-peen-ee-ah), a condition where the
body makes too few neutrophils.  Neutropenia may be a long-standing condition where
your body does not make enough neutrophils, or it may be caused by drugs used to treat
cancer.  In some cases, your body may make enough neutrophils, but as part of your
treatment for cancer, your doctor may want to increase the number of certain blood cells
(CD34 cells) and collect them.  The cells are collected using a process called apheresis
(ay-fer-ree-sis).  These collected cells are given back to you after you receive very high
doses of treatment for cancer to make your blood counts get back to normal more

How does NEUPOGEN® work?

NEUPOGEN® works by helping your body make more neutrophils.  To make sure
NEUPOGEN® is working, your doctor will ask that you have regular blood tests to count
the number of neutrophils you have.  It is important that you follow your doctor’s
instructions about getting these tests.   

Who should not take NEUPOGEN® ?

Do not take NEUPOGEN® if you are:
  • Allergic to NEUPOGEN® (Filgrastim) or any of its ingredients.  See the end of this leaflet for a list of ingredients in NEUPOGEN®.
  • Allergic to other medicines made using the bacteria E coli.  Ask your doctor if you are not sure.

What important information do I need to know about taking NEUPOGEN®?

NEUPOGEN® may reduce your chance of getting an infection, but does not prevent all
infections.  An infection can still happen during the short time when your/your child's
neutrophil levels are low.  You must be alert and look for some of the common signs or
symptoms of infection, such as fever, chills, rash, sore throat, diarrhea, or redness,
swelling, or pain around a cut or sore.  If you/your child has any of these signs or
symptoms during treatment with NEUPOGEN®, tell your doctor or nurse immediately.
There is a possibility that you could have a reaction at an injection site.  If there is a
lump, swelling, or bruising at an injection site that does not go away, call your doctor.
If you have a sickle cell disorder, make sure that you tell your doctor before you start
taking NEUPOGEN®. If you have a sickle cell crisis after getting NEUPOGEN®, tell your doctor right away.

Make sure your doctor knows about all medicines, and herbal or vitamin supplements
you are taking before starting NEUPOGEN®.  If you are taking lithium you may need more frequent blood tests.   

If you/your child are receiving NEUPOGEN® because you are also receiving chemotherapy, the last dose of NEUPOGEN®
 should be injected at least 24 hours before your next dose of chemotherapy.   

There is more information about NEUPOGEN® in the Physician Package Insert.  If you have any questions, you should talk to your doctor.

What are possible serious side effects of NEUPOGEN®?

• Spleen Rupture. Your spleen may become enlarged and can rupture while taking
NEUPOGEN®.  A ruptured spleen can cause death.  The spleen is located in the
upper left section of your stomach area.  Call your doctor right away if you or your
child has pain in the left upper stomach area or left shoulder tip area.  This pain
could mean your or your child’s spleen is enlarged or ruptured.
• Serious Allergic Reactions.  NEUPOGEN® can cause serious allergic reactions.  
These reactions can cause a rash over the whole body, shortness of breath,
wheezing, dizziness, swelling around the mouth or eyes, fast pulse, and sweating.  If
you or your child  starts to have any of these symptoms, stop using NEUPOGEN and
call your doctor or seek emergency care right away.   If you or your child has an
allergic reaction during the injection of NEUPOGEN®, stop the injection right away.
• A serious lung problem called acute respiratory distress syndrome (ARDS).  
Call your doctor or seek emergency care right away if you or your child has
shortness of breath, trouble breathing or a fast rate of breathing.  

What are the most common side effects of NEUPOGEN®?

The most common side effect you/your child may experience is aching in the bones and
muscles.  This aching can usually be relieved by taking a non-aspirin pain reliever such
as acetaminophen.
Some people experience redness, swelling, or itching at the site of injection.  This may
be an allergy to the ingredients in NEUPOGEN®, or it may be a local reaction.  If you are
giving an injection to a child, look for signs of redness, swelling, or itching at the site of
injection because they may not be able to tell you they are experiencing a reaction.  If
you notice any signs of a local reaction, call your doctor.

What about pregnancy or breastfeeding?  

NEUPOGEN® has not been studied in pregnant women, and its effects on unborn babies
are not known. If you take NEUPOGEN® while you are pregnant, it is possible that small
amounts of it may get into your baby’s blood. It is not known if NEUPOGEN® can get into
human breast milk.

If you are pregnant, plan to become pregnant, think you may be pregnant, or are breast
feeding, you should tell your doctor before using NEUPOGEN

Be sure to consult your doctor before taking any medication!

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